Curcumin Inhibits Formation of Amyloid Oligomers and Fibrils,
Binds Plaques, and Reduces Amyloid in Vivo*
Curcumin is widely used at low doses as a yellow food dye and at higher doses in traditional Indian “Ayurvedic” medicine, typically as a turmeric extract. Because of its use as a food additive and its potential for cancer chemoprevention, curcumin has undergone extensive toxicological screening and preclinical investigation in rats, mice, dogs, and monkeys (11, 48). ... Thus, our data showing low dose inhibition of amyloid oligomer and fibril formation as well as suppression in aged animals, combined with published antioxidant, anti-inflammatory, and antiamyloid activities in two animal models (15, 41), provide an increasingly compelling rationale for clinical trials for curcumin in the prevention or even treatment of AD.