Antioxidant Research

1.  Title

Inhibitory Effects of Maharishi-4 [MAK-4] and Maharishi-5 [MAK-5] on Microsomal Lipid Peroxidation


Pharmacology, Biochemistry and Behavior, Vol. 39, No. 3, pp. 649-652, 1991.


Chandradhar Dwivedi,* Hari M. Sharma,** Stacy Dobrowski,* and Ferzaan N. Engineer.*

Conducted at

* College of Pharmacy, South Dakota State University, Brookings, SD

~College of Medicine, The Ohio State University, Columbus, OH


The effects of Maharishi-4 (MAK-4) and Maharishi-5 (MAK-5) on microsomal lipid peroxidation were examined in vitro.... These findings suggest that MAK-4 and MAK-5, by virtue of their antioxidant properties, may be useful in the treatment of free radical-linked drug toxicities and disease states.



2.  Title

Effect of Maharishi 4 [MAK-4] and Maharishi 5 [MAK-5] on Inflammatory Mediators With Special

Reference to Their Free Radical Scavenging Effect


Indian Journal of Clinical Practice, Vol. I, No. 8, pp. 23-27, January 1991-


Yukie Niwa.

Conducted at

Niwa Institute for Immunology, Japan


Maharishi 4 (MAK-4) and Maharishi 3 (MAK-5) were investigated for their effects on human neutrophil chemotaxis, phagocytosis, reactive oxygen species (ROS) generation, and lymphocyte response to mitogens. The effect on ROS generated in a xanthine-xanthine oxidase system was also tested. Chemotaxis was significantly inhibited in the presence of MAK-4 and phagocytosis was slightly decreased in the presence of both MAK-4 and MAK-5. MAK-4 and MAK-3 markedly decreased superoxide, hydrogen peroxide, and hydroxyl radicals, generated both in the neutrophil and xanthine-