The beneficial effects of tea on immune function and inflammation: a review of evidence from in vitro, animal, and human research
Review Article
Mark Hamer Department of Epidemiology and Public Health, University College
London, WC1E 6BT London, UK
Nutrition Research 27 (2007) 373–379
Abstract
Traditionally, tea has been drunk to eliminate toxins and to improve resistance
to disease, although interest has mostly focused on cardiovascular disease risk
reduction. This article therefore reviews evidence for the beneficial effects of
tea flavonoids on immune function. The review focuses on key areas that include
innate immunity and upper respiratory tract infections, gut health, oral health,
and inflammatory processes. Important findings include the beneficial effects of
tea extracts on fecal microflora balance, although the minimum effective dose
requirements remain unclear. There is further evidence for the antimicrobial
effects of tea in the upper respiratory tract and in inhibiting the growth of
periodontal pathogens, although these effects have only been observed at high
concentrations. Modulating effects of tea on the immune cells and markers of
inflammation have been demonstrated, but robust data from human intervention
trials are lacking. In summary, there is evidence to suggest that tea may have
beneficial effects on certain immune parameters, which has implications for
improving gut health and resistance against infections such as the common cold.
However, further evidence from human studies, which control for potential
confounding from lifestyle and biological factors, is required before strong
conclusions can be made regarding the association between tea and immune
function.
© 2007 Elsevier Inc. All rights reserved.