Cancer Research

 

2.  Title

Antineoplastic Properties ofMaharishi Arnrit Kalash [MAK-5], An Ayurvedic Food Supplement, Against

7,12-Dimethylben2(a)anthracene-lnduced Mammary Tumors in Rats

Publication

Journal of Research and Education in Indian Medicine, Vol. 10, No. 3, pp. 1-8, July-September 1991

Authors

Hari M. Sharma,* Chandradhar Dwivedi,** Bryan C. Satter,** and Hussein Abou-lssa.*

 

Conducted at

* College of Medicine, The Ohio State University, Columbus, OH 43210

**College of Pharmacy, South Dakota State University, Brookings, SD 37007

 

Summary

The herbal mixture Maharishi Arnrit Kalash-5 (MAK-5) was tested for antineoplastic properties against 7,12- dimethylbenz(a)anthracene (DMBA)-induced

mammary tumors in rats. The 0.2% (w/w) MAK-5-supplemented diet protected against DMBA-induced carcinogenesis during the promotion phase by reducing both tumor incidence and multiplicity. MAK-3 provided up to 62.5% protection (p<0.03) during the promotion phase of carcinogenesis. Also, a MAK-3-supplemented diet fed for four weeks to control rats which had developed mammary tumors, decreased tumor size in 60% of these rats. There was no significant

difference in weight gain in rats on the MAK-5-supplemented diet. Thus, the MAK-5- supplemented diet did not influence the food intake, but protected against DMBA- induced mammary tumors in rats.

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TIME (WEEKS)

FIG. 2. Effect of 0.2% MAK-5-supplemented diet on tumor

incidence. Tumor incidence in all groups was statistically

analyzed using Chi-square test. The P and I+P groups were

significantly different from C group (p<0.03). Groups: C=control;

I=initiation; P=promotion; l+P=initiation and promotion.

 

TABLE 2.

CHANGE OF TUMOR VOLUME OF THE RATS IN THE REGRESSION GROUP TREATED WITH 0.2%

 

 

 

   MAK-5-SUPPLEMENTED DIET FOR FOUR WEEKS

CM3: CUBIC CENTIMETERS INCREASE IN TUMOR VOLUME DECREASE IN TUMOR VOLUME